In April 2019 the VPH project INSIST (In silico clinical trials for treatment of ischemic stroke) organised a discussion group to inform interested clinicians and to obtain their feedback on the concept, current state of the art, and intended further development of the project.
The INSIST project aims to develop an in silico platform for the simulation and evaluation of novel treatments for acute ischemic stroke. INSIST comprises the generation of virtual patient populations, the in silico modeling of brain tissue death due to the lack of oxygen and nutrients following a stroke, thrombosis and thrombolysis, and thrombectomy. The combination allows in silico simulation of (pre-) clinical trials.
In April 2019 Clinical Focus Group Discussions were
organised to inform interested clinicians and to obtain their feedback on the exploitation of the project. In short, the concept
of in silico stroke trials was considered promising, especially the thrombectomy modeling was
regarded valuable. The modeling of tissue death and its effect on clinical outcome was
considered the most complex and risky.
You can read the full details on the white paper.