Interface Focus Theme Issue featuring VPH2012 papers: Available Online

Theme Issue 'The virtual physiological human: integrative approaches to computational biomedicine' organized and edited by Peter Coveney, Vanessa Diaz-Zuccarini, Norbert Graf, Peter Hunter, Peter Kohl, Jesper Tegner and Marco Viceconti

April 6, 2013; Vol. 3, No. 2

Introduction

• Introduction: Integrative approaches to computational biomedicine

Peter V. Coveney, Vanessa Diaz-Zuccarini, Norbert Graf, Peter Hunter, Peter Kohl, Jesper Tegner, and Marco Viceconti

Interface Focus April 6, 2013 3 20130003; doi:10.1098/rsfs.2013.0003

http://rsfs.royalsocietypublishing.org/content/3/2/20130003.abstract.html 

Articles

• Research article: Towards an interactive electromechanical model of the heart

Hugo Talbot, Stéphanie Marchesseau, Christian Duriez, Maxime Sermesant, Stéphane Cotin, and Hervé Delingette

Interface Focus April 6, 2013 3 20120091; doi:10.1098/rsfs.2012.0091

http://rsfs.royalsocietypublishing.org/content/3/2/20120091.abstract.html 

• Research article: Where do the platelets go? A simulation study of fully resolved blood flow through aneurysmal vessels

L. Mountrakis, E. Lorenz, and A. G. Hoekstra

Interface Focus April 6, 2013 3 20120089; doi:10.1098/rsfs.2012.0089

http://rsfs.royalsocietypublishing.org/content/3/2/20120089.abstract.html 

• Research article: Impact of blood rheology on wall shear stress in a model of the middle cerebral artery

Miguel O. Bernabeu, Rupert W. Nash, Derek Groen, Hywel B. Carver, James Hetherington, Timm Krüger, and Peter V. Coveney

Interface Focus April 6, 2013 3 20120094; doi:10.1098/rsfs.2012.0094

http://rsfs.royalsocietypublishing.org/content/3/2/20120094.abstract.html 

• Research article: Flexible composition and execution of high performance, high fidelity multiscale biomedical simulations

D. Groen, J. Borgdorff, C. Bona-Casas, J. Hetherington, R. W. Nash, S. J. Zasada, I. Saverchenko, M. Mamonski, K. Kurowski, M. O. Bernabeu, A. G. Hoekstra, and P. V. Coveney

Interface Focus April 6, 2013 3 20120087; doi:10.1098/rsfs.2012.0087

http://rsfs.royalsocietypublishing.org/content/3/2/20120087.abstract.html 

• Research article: Integrating multi-scale data to create a virtual physiological mouse heart

Sander Land, Steven A. Niederer, William E. Louch, Ole M. Sejersted, and Nicolas P. Smith

Interface Focus April 6, 2013 3 20120076; doi:10.1098/rsfs.2012.0076

http://rsfs.royalsocietypublishing.org/content/3/2/20120076.abstract.html 

• Research article: Antenatal architecture and activity of the human heart

Eleftheria Pervolaraki, Richard A. Anderson, Alan P. Benson, Barrie Hayes-Gill, Arun V. Holden, Benjamin J. R. Moore, Martyn N. Paley, and Henggui Zhang

Interface Focus April 6, 2013 3 20120065; doi:10.1098/rsfs.2012.0065

http://rsfs.royalsocietypublishing.org/content/3/2/20120065.abstract.html 

• Research article: A novel computational sheep atria model for the study of atrial fibrillation

Timothy D. Butters, Oleg V. Aslanidi, Jichao Zhao, Bruce Smaill, and Henggui Zhang

Interface Focus April 6, 2013 3 20120067; doi:10.1098/rsfs.2012.0067

http://rsfs.royalsocietypublishing.org/content/3/2/20120067.abstract.html 

• Research article: Heterogeneous and anisotropic integrative model of pulmonary veins: computational study of arrhythmogenic substrate for atrial fibrillation

Oleg V. Aslanidi, Michael A. Colman, Marta Varela, Jichao Zhao, Bruce H. Smaill, Jules C. Hancox, Mark R. Boyett, and Henggui Zhang

Interface Focus April 6, 2013 3 20120069; doi:10.1098/rsfs.2012.0069

http://rsfs.royalsocietypublishing.org/content/3/2/20120069.abstract.html 

• Research article: A generalized mathematical framework for estimating the residue function for arbitrary vascular networks

Chang Sub Park and Stephen J. Payne

Interface Focus April 6, 2013 3 20120078; doi:10.1098/rsfs.2012.0078 (EXiS Open Choice)

http://rsfs.royalsocietypublishing.org/content/3/2/20120078.abstract.html 

• Research article: Modelling of the physiological response of the brain to ischaemic stroke

Piotr Orlowski, David O'Neill, Vicente Grau, Yiannis Ventikos, and Stephen Payne

Interface Focus April 6, 2013 3 20120079; doi:10.1098/rsfs.2012.0079

http://rsfs.royalsocietypublishing.org/content/3/2/20120079.abstract.html 

• Discussion: The immune system as a biomonitor: explorations in innate and adaptive immunity

Niclas Thomas, James Heather, Gabriel Pollara, Nandi Simpson, Theres Matjeka, John Shawe-Taylor, Mahdad Noursadeghi, and Benjamin Chain

Interface Focus April 6, 2013 3 20120099; doi:10.1098/rsfs.2012.0099

http://rsfs.royalsocietypublishing.org/content/3/2/20120099.abstract.html 

• Research article: Systems pharmacology of the nerve growth factor pathway: use of a systems biology model for the identification of key drug targets using sensitivity analysis and the integration of physiology and pharmacology

Neil Benson, Tomomi Matsuura, Sergey Smirnov, Oleg Demin, Hannah M. Jones, Pinky Dua, and Piet H. van der Graaf

Interface Focus April 6, 2013 3 20120071; doi:10.1098/rsfs.2012.0071

http://rsfs.royalsocietypublishing.org/content/3/2/20120071.abstract.html 

• Research article: Patient-specific fibre-based models of muscle wrapping

J. Kohout, G. J. Clapworthy, Y. Zhao, Y. Tao, G. Gonzalez-Garcia, F. Dong, H. Wei, and E. Kohoutová

Interface Focus April 6, 2013 3 20120062; doi:10.1098/rsfs.2012.0062

http://rsfs.royalsocietypublishing.org/content/3/2/20120062.abstract.html 

• Research article: Multi-scale computational models of the airways to unravel the pathophysiological mechanisms in asthma and chronic obstructive pulmonary disease (AirPROM)

K. S. Burrowes, J. De Backer, R. Smallwood, P. J. Sterk, I. Gut, R. Wirix-Speetjens, S. Siddiqui, J. Owers-Bradley, J. Wild, D. Maier, and C. Brightling

Interface Focus April 6, 2013 3 20120057; doi:10.1098/rsfs.2012.0057

http://rsfs.royalsocietypublishing.org/content/3/2/20120057.abstract.html 

• Research article: An integrative, translational approach to understanding rare and orphan genetically based diseases

Robert Hoehndorf, Paul N. Schofield, and Georgios V. Gkoutos

Interface Focus April 6, 2013 3 20120055; doi:10.1098/rsfs.2012.0055 (EXiS Open Choice)

http://rsfs.royalsocietypublishing.org/content/3/2/20120055.abstract.html 

• Research article: A novel medical image data-based multi-physics simulation platform for computational life sciences

Esra Neufeld, Dominik Szczerba, Nicolas Chavannes, and Niels Kuster

Interface Focus April 6, 2013 3 20120058; doi:10.1098/rsfs.2012.0058

http://rsfs.royalsocietypublishing.org/content/3/2/20120058.abstract.html 

• Research article: Navigating legal constraints in clinical data warehousing: a case study in personalized medicine

Benjamin R. Jefferys, Iheanyi Nwankwo, Elias Neri, David C. W. Chang, Lev Shamardin, Stefanie Hänold, Norbert Graf, Nikolaus Forgó, and Peter Coveney

Interface Focus April 6, 2013 3 20120088; doi:10.1098/rsfs.2012.0088

http://rsfs.royalsocietypublishing.org/content/3/2/20120088.abstract.html 

• Research article: The PredictAD project: development of novel biomarkers and analysis software for early diagnosis of the Alzheimer's disease

Kari Antila, Jyrki Lötjönen, Lennart Thurfjell, Jarmo Laine, Marcello Massimini, Daniel Rueckert, Roman A. Zubarev, Matej Orešič, Mark van Gils, Jussi Mattila, Anja Hviid Simonsen, Gunhild Waldemar, and Hilkka Soininen

Interface Focus April 6, 2013 3 20120072; doi:10.1098/rsfs.2012.0072

http://rsfs.royalsocietypublishing.org/content/3/2/20120072.abstract.html 

• Research article: On-lattice agent-based simulation of populations of cells within the open-source Chaste framework

Grazziela P. Figueredo, Tanvi V. Joshi, James M. Osborne, Helen M. Byrne, and Markus R. Owen

Interface Focus April 6, 2013 3 20120081; doi:10.1098/rsfs.2012.0081

http://rsfs.royalsocietypublishing.org/content/3/2/20120081.abstract.html 

• Research article: A digital patient for computer-aided prosthesis design

Giorgio Colombo, Giancarlo Facoetti, and Caterina Rizzi

Interface Focus April 6, 2013 3 20120082; doi:10.1098/rsfs.2012.0082

http://rsfs.royalsocietypublishing.org/content/3/2/20120082.abstract.html 

• Research article: Applications of analysis of dynamic adaptations in parameter trajectories

Natal A. W. van Riel, Christian A. Tiemann, Joep Vanlier, and Peter A. J. Hilbers

Interface Focus April 6, 2013 3 20120084; doi:10.1098/rsfs.2012.0084 (EXiS Open Choice)

http://rsfs.royalsocietypublishing.org/content/3/2/20120084.abstract.html 

• Research article: Multiscale modelling of insulin secretion during an intravenous glucose tolerance test

Morten Gram Pedersen and Claudio Cobelli

Interface Focus April 6, 2013 3 20120085; doi:10.1098/rsfs.2012.0085

http://rsfs.royalsocietypublishing.org/content/3/2/20120085.abstract.html 

• Research article: Risk factor-dependent dynamics of atopic dermatitis: modelling multi-scale regulation of epithelium homeostasis

Elisa Domínguez-Hüttinger, Masahiro Ono, Mauricio Barahona, and Reiko J. Tanaka

Interface Focus April 6, 2013 3 20120090; doi:10.1098/rsfs.2012.0090 (EXiS Open Choice)

http://rsfs.royalsocietypublishing.org/content/3/2/20120090.abstract.html 

• Discussion: A vision and strategy for the virtual physiological human: 2012 update

Peter Hunter, Tara Chapman, Peter V. Coveney, Bernard de Bono, Vanessa Diaz, John Fenner, Alejandro F. Frangi, Peter Harris, Rod Hose, Peter Kohl, Pat Lawford, Keith McCormack, Miriam Mendes, Stig Omholt, Alfio Quarteroni, Nour Shublaq, John Skår, Karl Stroetmann, Jesper Tegner, S. Randall Thomas, Ioannis Tollis, Ioannis Tsamardinos, Johannes H. G. M. van Beek, and Marco Viceconti

Interface Focus April 6, 2013 3 20130004; doi:10.1098/rsfs.2013.0004

http://rsfs.royalsocietypublishing.org/content/3/2/20130004.abstract.html