This special edition of the VPHi Keynote Webinar Series took place on 03 May 2019 at 15 CET featuring the winners of the VPHi best thesis in in silico medicine: Jan Bruse and Francesc Levrero-Florencio, who graduated respectively at UCL and University of Edinburgh.
Francesc Levrero-Florencio (Research Associate in Computational Cardiovascular Science) finished his PhD in Civil Engineering at the University of Edinburgh in the topic of multiscale solid mechanics and HPC applied to trabecular bone, where he also developed a nonlinear version of ParaFEM, supported through an ARCHER RAP award. Francesc joined the CCS Group in November 2016 as part of the CompBioMed project, in close collaboration with the Barcelona Supercomputing Center. His research topic is the study of the multiscale electromechanical behaviour (contractility) of the human heart under healthy and diseased conditions.
Presentation Title: Multiscale modelling of trabecular bone: from micro to macroscale
Trabecular bone has a complex and porous microstructure. This study develops approaches to determine the mechanical behaviour of this material at the macroscopic level by developing models of its microstructure and computationally subjecting them to mechanical loading. It also provides an assessment of how the mechanical behaviour of trabecular bone at the macroscale, i.e. organ level, is affected by the mechanical behaviour at lower scales.
Jan Bruse studied Mechanical Engineering with specialisation in Textile and Medical Engineering at RWTH Aachen University, Germany. Funded by the IDEA League Student Research Programme he completed his final diploma thesis at the Department of Bioengineering at Imperial College London, UK under Dr Sandra Shefelbine, analysing a novel micro-indentation technique and its ability to assess fracture toughness of bone.
From 2013 onwards, he conducted research on statistical shape modelling of cardiovascular structures in congenital heart disease at University College London and Great Ormond Street Hospital for Children under Prof Silvia Schievano, Prof Tain-Yen Hsia and Prof Andrew M Taylor, financed by a Leducq studentship. He concluded his PhD thesis, which combines statistical modelling, data mining, medical image analysis and fluid flow simulations in 2017.
Currently, Jan is working as a research engineer and project manager at Vicomtech, a technology centre in San Sebastian, Spain, developing and implementing novel machine learning, data mining and advanced visualisation tools within applied R&D projects. Jan has published 15 peer-reviewed journal publications, has won three best paper awards and is reviewer for BMC Medical Imaging and Medical & Biological Engineering & Computing.
Presentation Title: Shape and function in congenital heart disease: a translational study using image, statistical and computational analyses.
The talk introduces basic concepts of statistical shape modeling and in particular highlight some interesting applications in the field of biomedical engineering.
The VPHi keynote webinar series is a quarterly event organized by the VPHi Student Committee that provides a forum for access to senior community members and their expert competence for chiefly young scientists, but also to the VPH community as a whole.
The webinar is organised and moderated by Ben Czaja from University of Amsterdam active member of the VPHi Student Committee.