JRC’s EURL ECVAM hosted meeting with OECD on Good In Vitro Method Practice (GIVIMP)

The JRC’s EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) hosted a meeting with OECD experts to discuss the draft of a guidance document on Good In Vitro Method Practice (GIVIMP) on the 23rd and 24th of March 2017.

This GIVIMP document is meant to serve as a technical guidance on good scientific and quality practices to support the regulatory human safety assessment of chemicals using in vitro methods.

Key points:

  • Validation studies have revealed that many in vitro methods need serious improvements in design, robustness and reliability in order to be successfully implemented and generate data sets which can be used to support regulatory decisions.
  • In this regard, the OECD asked the JRC EURL ECVAM to coordinate the drafting of a guidance document on Good In Vitro Method Practices (GIVIMP) for the development and implementation of in vitro methods for regulatory use in human safety assessment.
  • During the meeting the JRC’s EURL ECVAM will prepare the final GIVIMP version, which will be submitted for adoption by the OECD in April 2017.
  • The purpose of the GIVIMP guidance document is, to ensure that the overall process - from in vitro method development to in vitro method implementation for regulatory use - becomes more efficient and effective, taking into account all necessary good scientific, technical and quality practices.

Background:

  • Safety testing of chemicals is required to assess the hazards and potential risks of chemicals to humans. Historically, in vivo tests in laboratory animals have formed the foundation of hazard and risk assessment.
  • The European Union Reference Laboratory for alternatives to animal testing (EURL ECVAM) has been formally established in 2011, due to the increasing need for new methods to be developed and proposed for validation in the European Union. EURL ECVAM is hosted by the Joint Research Centre located in Ispra, Italy. 


Date: 07/04/2017 | Tag: | News: 580 of 632
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