The candidates will be contracted for three years and working in the frame of the EU funded research project: āSimulation of Cardiac Devices & Drugs for in-silico Testing and Certificationā (SimCardioTest), Call H2020-SC1-DTH-2018-2020, Research and Innovation Action (Topic SC1-DTH-06-2020).
The Cardiac Modeling Group belongs to the Electronics Engineering Department of the Polytechnical University of Valencia (UPV), Spain. The group is integrated by 5 faculty members and a variable number of post-doctoral and PhD students. We seek two highly motivated candidate (predoctoral or postdoctoral) to develop computational multiscale personalized models of the electrical activity of the heart to enable the in silico testing of drug efficacy and safety under healthy and pathological conditions.
The group has ample experience in modeling and simulating the electrical activity of the heart. Throughout our cardiac simulation work, we have developed and analyzed cardiac action potential (AP) models of different tissues (atrium, ventricle, and Purkinje) and different animal species (dog, rabbit, guinea pig, and human) under normal and under several pathological conditions, such as ischemia, heart failure, atrial fibrillation, and mutations. The group also has valuable experience in modeling the effects of drugs on different ionic channels. Moreover, we have developed computational tools for the simulation of the electrophysiological activity of a variety of tissue structures (unicellular, one-dimensional, bi-dimensional and tri-dimensional).
The candidate will develop cellular to 3D cardiac personalized models to simulate the effects of drugs on the electrical activity of the heart. Methods of image processing and mathematical modeling will be used to achieve the objectives. The candidate will receive data from our collaborators from the clinical and pharmaceutical field to build realistic and personalized models, as well as population of models considering variability and uncertainty. CONTRACT DETAILS: Applications: February 2022
Initial date: March-April 2022
Duration: 3 years at full and exclusive dedication. QUALIFICATIONS: