One candidate will be selected for a selective fellowship proposed by the AAP DIM 2015 «Problématiques transversales aux systèmes complexes»: deadline Feb 15, 2015
Proposed project: Computer modelling of immune system complexity and lymphocyte dynamics
General research aim: Global analysis and computer modelling of the immune system as a complex multi-scale heterogeneous adaptive, biological system.
Project: This interdisciplinary project aims to develop a more thorough understanding of the complexity of the immune system that behaves like a micro-ecological system by rapid adaptation to a changing environment by cell differentiation, cell death, cell selection, molecular and cell interaction, migration and complex dynamics regulations, by processes involving multi-scale biological levels from molecules to organism. Computational modelling of structural relationships and mathematical modelling of lymphocyte dynamics are required for a better understanding and simulations of the complex immune system behaviour in to understand the resilience and robustness in health but alterations in aging and diseases.
The PhD project aim is to develop a multi-scale computer model platform of lymphocytes dynamics. Our systems-biology approach favours global rather than reductionist approach and aims to develop simultaneously strategic tools to favour data storage, analysis, modelling and sharing in the team and with collaborators. The project uses UML as a lingua franca for encoding and sharing knowledge between research sub-groups, which are individually focused on knowledge-management, simulation and analysis. The candidate will be joining the project at a key point in its development. Initial work to develop the necessary framework to describe current biological knowledge will be complete. The aim of the PhD project will be to develop the computer platform allowing for population or agent based models and simulations, integration of ontologies to design a platform using graphical and standardized languages, with an interface designed to help biologist to program and run their model and fit on experimental data to validate them. Indeed, originally applied to mice, the modelling tools will be extended for modelling the immune system behaviour of patients in the context of TransImmunom LabEx and as underlined in the Virtual Physiological Human VPH conference. This model could be in turn applied to other population-/agent-based models such as social or ecological systems.
Candidates should have solid computational (UML, java, xml, ontologies, standard languages), mathematical and statistical experience with a strong motivation for biological modelling, and interest in complex systems behaviour to test robustness and resilience of the system. Background in Immunology is welcome.
Bibliographical references related to the project
See publication here: http://www.immunocomplexit.net/
Related team publications
Dr Véronique THOMAS-VASLIN/ Prof. Adrien SIX
Phone: +33 01 42 17 74 66
Email: firstname.lastname@example.org /email@example.com
Institution: UPMC, INSERM, CNRS
Unit Director: Prof. David KLATZMANN,
Immunology, Immunopathology, Immunotherapy
CNRS FRE3632, UPMC INSERM UMRS959
83 Boulevard de l’Hôpital, 75013 Paris
Additional information can be found at: http://www.iscpif.fr/tiki-index.php?page=aap15_doc